According to the scientists from the University of Washington, the brain can become a new target of type 1 diabetes therapy. They found that Lepti hormone can stabilize blood sugar, even in case of acute insulin deficiency. The results of the study were published in the magazine of "Clinical Research" (JCI).
In case of diabetes, the insulin hormone is unable to perform his functions, as a result of a stable increase in glucose levels. In severe cases, this can lead to the development of diabetic dots. This is an acute and potential life-threatening complexity, in which case the body is accumulated in the body, and the metabolic criminal is developing.
In the case of DKA, the body begins to produce energy from glucose but fat. At the same time, the function of the kidneys can be disturbed, fatigue, headache, confusion, breathing difficulty and nausea.
Until now, it was considered that the only way to stop the DKA is insulin injection. However, experiments on mice have shown that the concentration of glucose and doton bodies is normalized in case of Leptine's direct injection and remains stable without insulin therapy.
Researchers explain: When there is a shortage of insulin, the brain is perceived as an energy crisis, intensifying glucose emergency mobilization mechanisms. Leptin's lack of leptin, which signals fat reserves, strengthens this reaction. With the immediate use of Leptine, scientists managed to "deceive" the brain and prevent the sharp rise in the sugar level.
The team is already preparing for FDA (US Food and Drug Department) to conduct clinical trials. In case of success, a new strategy may be made in the treatment of type 1 diabetes without permanent injections and permanent sugar monitoring.
Translation of: Euromedia24.com
