Walter and Eliza Hall Medical Research Institute (Australia) researchers offered the treatment of aggressive cancer, blocking the rare molecular process called small dissusciation. As mentioned in the Embo Reports magazine, pressure on this mechanism slows significantly increases the growth of liver, lungs and stomach tumors, leaving healthy cells almost harmlessly.
Small splaying is a special type of RNA "editing" that affects only about 0.05% of all genes. However, these genes play an important role in the division of cells and actively participate in the development of malignant tumors, especially those that contain KRAS mutation, which is one of the most reluctant and difficult-being treated.
Scientists have found that the intervention in this process causes DNA damage and activates P53 protein, the most important defense mechanism of the body, which stimulates the self-destruction of cells in mutations.
Attempts on mice, fish and laboratory cells have shown that another protein, RNPC3's reduction, which participates in small dissuscatory, significantly reduces the burden of tumor. At the same time, the impact on healthy tissue remains minimal.
Now the research team is looking for compounds that can selectively suppress minor spraying. In the future, this can lead to a new class of anti-tumor drugs, especially for the treatment of cancer forms that "do not respond" to the existing methods of therapy.
Translation of: Euromedia24.com
