Protein Ribonukletshaz 4 (RNASE4), which is produced by pancreas by beta cells, can promote their division and help control the blood sugar level. This conclusion was reached by the researchers of the University of Zhetszzyan. The results of the study were published in Science Bulletin magazine.
In the past, scientists have already searched for molecules that can promote the basic "factories" of beta cells, insulin. However, almost everyone in them came from other organs. RNASE4 was the first protein that is produced just in the pancreas and directly affects the cell recovery.
It is noted that insulin hormone allows texture cells, particularly muscular and fat cells, absorb glucose from blood. This helps reduce blood sugar levels, spend and accumulate energy. Insulin regulation disorders in the body testify to the malfunctions of the endocrine and can lead to serious diseases such as diabetes.
Attempts on mice have shown that in case of RNASE4 deficiency, the clusters of cells producing the pancreas, Langerhan's islands are decreased. The insulin level is decreasing, while the glucose level is rising in the blood. On the contrary, the import of RNASE4 promotes even the division of damaged cells and normalizes blood sugar levels.
According to scientists, the molecule operates through a TXL receptor, activating the signal cascade, which stimulates cells.
The authors believe that RNASE4 can be a basis for new diabetes treatment or type 1 or 2. Protection of protein to the pancreas will not only reimburse the loss of beta cells, but will restore their function, reducing their dependence on insulin.
Translation of: Euromedia24.com
