Chinese scientists at the University of Shandun have discovered a key role in the development of the velvetious protein (IDD) of Ferreraptosis, the main cause of chronic backs of the back. Discovery can pave the way for new treatment methods that can alleviate millions of people suffering around the world. The study was published in the GENES & DISEASES (G & D) scientific journal.
The pain of the waist is one of the most common health problems that suffers from more than 70% of people. The degeneration of the interi-series disks caused by chronic inflammation is the main reason for this pain. However, the molecular mechanisms underlying the disk degeneration remain poorly understood.
Researchers have found that inflammatory TNFA cytokin activates FSP1 protein, which in turn causes apoptosis (mobile death) and mentochondrial damage in the cells of the midst of the midline. This leads to their perversion and chronic pain.
"We found that FSP1 plays a central role in the degeneration of a disk mediated by TNFA. This discovery offers a new therapeutic target for the treatment of chronic pain in the back, "said the leading author of the study physician.
Attempts have shown that FSP1 braking reduces apoptoz and mitochondrial dysfunction, confirming its key role in the development of the IDD. However, FSP1 braking does not cause ferraptosis, another type of cell destruction, making it a safe target of therapy.
Discovery opens new opportunities for processing drugs against FSP1 that can slow down or even reverse the degeneration of the interi-series disks.
Translation of: Euromedia24.com
