Scientists have found that one of the reassure of the recidivism of the aggressive brain cancer (return) of the aggressive brain cancer in children may be the elements of the relapse (return) of an aggressive brain cancer. The results of the study were published in the Cancer Discovery (CD) magazine.
The VACTAs emerge when the DNA sections are turned off from KROM through mesomomes and joins the restoration of genetic material. Such ring structures are found in solid tumors in children more often than they have previously assumed. Their existence is related to the unfavorable treatment forecast.
Attempts on mice to mobile lines have shown that the tumor cells that have many copies of Mycn Oncogen in VERDD, but they are better responding to chemotherapy. In contrast, cells that have few copies of this onkogen, pass the aging phase. According to scientists, they turn into unique "zombie-cells" that stop multiplying, but remain in the body.
It is this second-type cancer cells that can be stir again after one or two years of therapy, causing relapse. These cells are also stable to standard treatment methods.
The combination of traditional chemotherapy in the experiments performed on mice has significantly improved the results of the destruction of aging cells.
"We strive to create new drugs and their combinations that will increase the growth of the tumor, eliminating this onkogen ring DNA elements. Our goal is to turn scientific disclosures into children's brain cancer more efficient and long-term treatment, "said the co-author of the study Lucas Chavez.
Translation of: eiromedia24.com
