Bone marrow transplant can prevent the development of a rare and deadly disease, in which case the brain cells are "fail." This conclusion was based on the scientists of the Jiahotong University of Shanghai. The results were published in the science magazine.
It's about Leicoencephalopathy with Axonal Sferoid and Pigmented Gli (ALSP). AlSP emerges from the mutation of CSF1R gene, due to which microglia, brain cells are destroyed. This leads to the accumulation of damaged neurons, tissue calcification, damage to nervous fibers, and the development of motor and cognitive disorders. To date, there was no effective treatment for studying the disease, nor an appropriate animal model.
Researchers have created two csf1r mutations, which have developed all the main features of AlSP. Then they tested a bone marrow transplant. Even the transplantation of additional interventions was effective. Due to the weakening of his own microglias, the new cells quickly replaced it.
The method was also tested on humans, eight patients with a bone marrow transplanted by AlSP. Two years after the operation, the disease did not develop, the mutations were eliminated in cells.
According to the authors, this opens out the approach to applying this approach to other diseases related to microglias' dysfunction. These include some forms of Demension. Scientists say that the method of wide application of the method needs to be found optimal balance between the efficiency of cell replacement and the security of the procedure.
Translation of: Euromedia24.com
