Researchers at the Cancer Center of Ohio State University revealed a hidden biological process, which leads to "exhaustion" of the main fighters of the immune system. The study was published in Nature magazine.
T cells recognize infections and tumor cells, but over time they lose their activity and stop preventing cancer growth. Scientists have found that exhausted T cells accumulating incorrectly folded proteins that cause previously unknown stressful path, called TexPPSR (Proteotoxic Stress Reaction). TexPPPSR, which is different from typical mobile protection mechanisms, increases protein synthesis, rather than reduces it. This leads to the occurrence of poisonous aggregates like Amyloid Vahans of Alzheimer's disease, poisoning cells and making them helpless.
When researchers blocked TexPPSR's main driving forces, T cells recovered their ability to attack tumors, and immunosomacy increased dramatically.
"T cell distress oncology is the main obstacle. Our results give an unexpected answer to this fundamental issue and can play a crucial role in developing new anti-cancer therapies, "said Professor Zihay Lin.
The patient's analysis has shown that TexPPPPP level is associated with poor clinical results. This confirms that this new path can become an important target of future medicines.
Translation of: Euromedia24.com
